Tianhui Wu; Ziming Chen; Xin Liu; Xinyan Wu; Zhaobo Wang; Weiqiang Guo
Anti-cancer agents in medicinal chemistry (Print),
2025
25
(1)
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SCIE
摘要 : P90 ribosomal S6 kinase 2 (RSK2) is an important member of the RSK family, functioning as a kinase enzyme that targets serine and threonine residues and contributes to regulating cell growth. RSK2 comprises two major functional domains: the N-terminal kinase domain (NTKD) and the C-terminal kinase domain (CTKD). RSK2 is situated at the lower end of the Mitogen-activated protein kinases (MAPK) signaling pathway and is phosphorylated by the direct regulation of Extracellular signal-regulating kinase (ERK). RSK2 has been found to play a pivotal role in regulating cell proliferation, apoptosis, metastasis, and invasion in various cancer cells, including breast cancer and melanoma. Consequently, RSK2 has emerged as a potential target for the development of anti-cancer drugs. Presently, several inhibitors are undergoing clinical trials, such as SL0101. Current inhibitors of RSK2 mainly bind to its NTK or CTK domains and inhibit their activity. Natural products serve as an important resource for drug development and screening and with the potential to identify RSK2 inhibitors. This article discusses how RSK2 influences tumor cell proliferation, prevents apoptosis, arrests the cell cycle process, and promotes cancer metastasis through its regulation of downstream pathways or interaction with other biological molecules. Additionally, the paper also covers recent research progress on RSK2 inhibitors and the mechanisms of action of natural RSK2 inhibitors on tumors. This review emphasizes the significance of RSK2 as a potential therapeutic target in cancer and offers a theoretical basis for the clinical application of RSK2 inhibitors.
Tianli Zhang; Pengfei Yu; Xingmei Guo; Yuanjun Liu; Xiangjun Zheng; Zhongyao Duan
Journal of Colloid and Interface Science,
2025
679
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EI
SCIE
摘要 : Simultaneously dispersing phosphide crystallites and multiple heteroatoms in hollow carbon is a significant yet challenging task for achieving high-performance oxygen electrocatalysts of zinc-air batteries. Herein, a simple wrapping-pyrolysis strategy is proposed to prepare Co 2 P/CoP embedded in N, P, S triply-doped hollow carbon (Co 2 P/CoP@NPS-HC). Co 2 P/CoP@NPS-HC composite features hollow polyhedral structure populated with numerous catalytically active Co 2 P/CoP nanoparticles and N, P, S heteroatoms. This optimized catalyst exhibits excellent activity for oxygen reduction reaction, with a half-wave potential of 0.82 V vs. RHE, and impressive enhancement for oxygen evolution reaction, indicated by an overpotential of 400 mV at 10 mA cm −2 . Moreover, Co 2 P/CoP@NPS-HC catalyst exhibits greater durability and superior methanol tolerance compared to commercial Pt/C. The excellent bifunctional electrocatalytic performance of Co 2 P/CoP@NPS-HC catalyst is attributed to the synergistic effect of uniformly dispersed Co 2 P/CoP nanoparticles and N, P, S triply-doped hollow carbon structure. The former provides abundant catalytically active sites, while the latter offers a high accessible specific surface area, as well as enhances catalytic activity and electronic conductivity due to its altered charge distribution.
Li Tian; Tao Hu; Yawen Guo; Peng Ju; Xiujuan Chen; Yueming Li
Journal of Colloid and Interface Science,
2025
679
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EI
SCIE
摘要 : The design of self-supporting structure is particularly important to improve the stability and electrochemical performance of hydrogen evolution reaction electrode. Here, a facile strategy for building novel ultra-stable 0D-2D-3D integrated self-supporting electrode with high conductivity, sufficient diffusion channels and large reactive surface area was proposed. In the heterostructure, 2D Ti 3 C 2 T x flakes in-situ synthesized on 3D network porous Ti 3 AlC 2 surface which provides the multiple reactive surface areas and aggregation resistance to facilitating 0D ultrafine Pt nanoparticles uniform anchorage. Combined with structural characterization and first-principles calculations revealed that, the highly dispersed ultrafine Pt synergistically coupling strong metal-support interactions creates a unique multifunctional catalytic interface with high stability and atomic utilization efficiency of Pt to promote the HER in acidic and seawater. The resultant self-supporting electrode (support 0.48 wt% Pt) exhibits much superior activity to 10 % commercial Pt/C (loaded on foam nickel) in 0.5 M H 2 SO 4 (55 mV@10 mA cm −2 ) and simulate seawater (196 mV@10 mA cm −2 ) while reducing the Pt usage by 15 times. Meanwhile, the electrode also illustrates outstanding stability under high current densities (100 h@100 mA cm −2 ). This study provides a new design idea for developing integrated self-supporting catalytic electrodes to meet the durability of hydrogen evolution reaction applications in harsh environments.
Yongqiang Chen; Olivia X. M. Yao
Journal of combinatorial theory. Series A (Print),
2025
210
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SCIE
摘要 : In 2012, Andrews and Merca investigated the truncated version of the Euler pentagonal number theorem. Their work has opened up a new study on truncated theta series and has inspired several mathematicians to work on the topic. In 2019, Merca studied the Rogers-Ramanujan functions and posed three groups of conjectures on truncated series involving the Rogers-Ramanujan functions. In this paper, we present a uniform method to prove the three groups of conjectures given by Merca based on a result due to Pólya and Szegö.
Yingcheng Wu; Jing He; Kang Zhong; Sibo Wang; Xianglin Zhu; Xiaojie She
Separation and Purification Technology,
2025
354
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EI
SCIE
摘要 : 3D printed monolithic catalysts have attracted increasing attention in the petrochemical industry due to their advantages of the freedom of configuration, the rapidity of fabrication and the control of the fluid properties of the reaction medium. However, this remains challenging in constructing of micromorphology, reliable manufacturing, and adaptive functionality. Herein, inspired by the function of acicular plant fractal structure, we have developed bionic multistage monolithic catalysts based on direct photo-curing 3D printing technology. We also design two configuration strategies for static and dynamic oxidative desulfurization of fuels. Below the catalyst surface, the porous structure prepared by the hard template method can increase the specific surface area of the catalyst to disperse the active center and adsorb organic sulfur to strengthen the oxidation effect. The 3D-MoWO/PC-CE monolithic catalyst shows excellent activity in the static reaction with 100% sulfur removal. Above the catalyst surface, microcrystalline cellulose is introduced in-situ in 3D printed ink to build needle-like structures to enhance mass transfer efficiency and reduce surface pressure in dynamic fixed bed reaction. This work provides valuable ideas for the fabrication of efficient monolithic catalysts in various reactions.
Jiaojiao Sun; Xingyang Lv
Tourism Management,
2025
106
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SSCI
摘要 : "Red tourism" serves political and educational functions. It could take dark tourism sites as the spatial basis for constructing the red experience, with patriotism cultivation as the result. Taking the Memorial Hall of the Victims in Nanjing Massacre by Japanese Invaders as a case study, this research integrates field survey data, spatial luminosity, and user-generated content. It explores how the museum space unifies the spiritual production of body (visual darkness), experience (dark and red experiences), and patriotism, illustrates how the official discourse constructs the sites as a red experience, and demonstrates the process of transforming abstract history into individual psychological experiences through bodily and personal narration. Furthermore, this research constructs an approach from individual to collective emotion and the production mechanism of patriotism. The study offers a new reference for tourism experience and provides a highly representative case and theoretical analysis for "dark" and "red" tourism.
Youcun Bai; Zhixian Wu; Qidong Lv; Wei Sun; Wenhao Liang; Xin Xia
Journal of Colloid and Interface Science,
2025
679
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EI
SCIE
摘要 : Vanadium-based oxides have good application prospects in aqueous zinc ion batteries (AZIBs) due to their structures suitable for zinc ion extraction and intercalation. However, their poor conductivity limits their further development. The d-band center plays a key role in promoting adsorption of ions, which promotes the development of electrode materials. Here, a series of MoV 2 O 8 compounds with oxygen defect (O d -MoV 2 O 8 ) were synthesized by a simple hydrothermal process and a subsequent vacuum calcination process through strict control of the deoxidation time. Theoretical calculations reveal that the abundant oxygen vacancies in MoV 2 O 8 effectively regulate the d-band center of the zinc ion adsorption site. This precise control of the d-band center enhances the zinc ion adsorption energy of MoV 2 O 8, lowers the migration energy barrier for zinc ions, and ultimately significantly boosts zinc storage performance. The specific capacity is as high as 282.4 mAh/g after 100 cycles at 0.1 A/g, and it also shows excellent performance and outstanding cycle life. In addition, the maximum energy density of O d -MVO-0.5 (MoV 2 O 8 sample deoxidized for 0.5 h) is 343.3 Wh kg −1 . Importantly, the mechanism of Zn 2+ storage in O d -MoV 2 O 8 was revealed by the combination of in situ and ex situ characterization techniques.
Xing Zhang; Wenbin Yu; Wenjing Shao; Zihan He; Yingzhou Lu; Yuting Xin
Aquaculture,
2025
595
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SCIE
摘要 : The largemouth bass ( Micropterus salmoides ) is a well-known freshwater fish species that is commonly bred in aquaculture. Unfortunately, this species faces a significant threat from viral diseases, and there is currently no available vaccine to combat them. In this study, we have conducted viral metagenome analysis to explore the RNA virome of largemouth bass, which refers to the collection of all RNA viruses present in the fish. It revealed the existence of 69 known viruses and 117 novel viruses in the liver, spleens, and kidneys of largemouth bass. The diverse range of viruses suggests that their host range may be wider than previously believed. Interestingly, many of the viruses identified in largemouth bass bear similarities to known pathogens found in nonaquatic animals, such as bovine viral diarrhea virus 1 and 2, porcine endogenous retrovirus, feline sarcoma virus, avian sarcoma virus 16, mouse mammary tumor virus, and mammalian orthoreovirus 5. This finding indicates the potential for these viruses to be transmitted across different species to largemouth bass. To confirm the presence of these viruses, reverse PCR and Sanger sequencing were employed to explore the authenticity of the identified RNA viruses. The discovery of this hidden diversity within the RNA virome of juvenile largemouth bass brings attention to the latent viruses that pose a serious threat. Further investigation is crucial to understanding the pathogenicity of these viruses and developing effective measures for disease prevention in largemouth bass aquaculture.
Yu Shen; Yuhan Wang; Pengnian Shan; Rui Xu; Xinhai Sun; Jianhua Hou
Separation and Purification Technology,
2025
353
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EI
SCIE
摘要 : Photo-Fenton process is acknowledged for its high efficiency and technical feasibility in water treatment; however, its application is constrained by the addition of iron ions and hydrogen peroxide (H 2 O 2 ). Herein, an efficient photo-self-Fenton system with coating Fe-doped carbon dots (Fe-CDs) on the surface of highly crystalline C 3 N 5 (HC-C 3 N 5 ) nanosheets was developed for degradation of tetracycline (TC) under visible light irradiation. Experimental results reveal that Fe-CDs not only serve as active sites for facilitating superior light-induced charge separation and transfer towards the in-situ generation of H 2 O 2 over HC-C 3 N 5, but also provide the solid-phase Fe species for maximizing the activation of in-situ generated H 2 O 2 to produce highly oxidative OH and O 2 – species towards the photo-self-Fenton reaction. This research presents a novel design approach of utilizing a Fe-CDs-based photo-self-Fenton system for efficient wastewater treatment.
Bofan Zhang; Mengyi Zhao; Kai Cheng; Juanjuan Wu; Shiro Kubuki; Liang Zhang
Coordination Chemistry Reviews,
2025
523
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SCIE
摘要 : The swift progression of industrialization poses a profound threat to environmental integrity, giving rise to environmental pollution and a consequential imbalance in ecosystems, thereby compromising public health. Consequently, the exigency for environmental remediation has become both urgent and imperative. Within this context, the burgeoning research field of piezoelectric catalysis has ushered in transformative and sustainable advancements in catalytic processes, untethered from the reliance on luminous energy or electricity inputs. This novel approach exhibits efficacy in generating reactive substances tailored to combat refractory contaminations. This comprehensive review delineates state-of-the-art progressions in piezoelectric materials, characterization instruments, mechanisms, and their applications in environmental decontamination. The exploration encompasses piezoelectric catalysis, piezo-photocatalysis, and various piezo-Fenton-like processes, including piezocatalytic H 2 O 2 evolution, piezo-self cycled Fenton-like, and piezocatalytic persulfate and ozonation. A meticulous exposition begins with a detailed analysis of conventional and emerging piezoelectric materials, accompanied by a discussion on effectual and popular characterizations. The subsequent sections delve into the prevailing origin of the piezoelectric effect, prerequisites, improving strategies, and unresolved issues pertaining to the discernment of piezocatalytic mechanisms. Further, this review systematically explores the application of piezoelectric-coupled advanced oxidation processes and their intrinsic mechanisms in organic decontamination, H 2 O 2 evolution, heavy metal reduction, bacterial disinfection, and CO 2 reduction. In conclusion, the paper articulates the challenges inherent in piezocatalytic techniques and proposes directions for future development. The aim is to contribute to an enhanced foundational understanding of piezoelectric catalysis and piezoelectric-based Advanced Oxidation Processes (AOPs) as potent tools for addressing contemporary environmental challenges.