成果筛选
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筛选条件 : Fangxin HU
Ying Yuan; Bo Chen; Xingxing An; Zhanhang Guo; Xin Liu; Hao Lu
Advanced healthcare materials, 2024 13 (20) - EI SCIE

摘要 : The emerging cell death modality of ferroptosis has garnered increasing attention for antitumor treatment but still suffers from low therapeutic efficacy. A metal–organic frameworks (MOFs)-based magnetic nanozyme (PZFH) comprising porphyrin-based Zr-MOF (PCN) on zinc ferrite (ZF) nanoparticles modified with hyaluronic acid, delivering excellent magnetophotonic response for efficient ferroptosis, is reported here. PZFH shows multienzyme-like cascade activity encompassing a photon-triggered oxidase-like catalysis to generate O2−, which is converted to H2O2 by superoxide dismutase-like activity and subsequent ·OH by magneto-promoted peroxidase (POD) behavior. Newly formed Fe─N coordination and increased Fe2+/Fe3+ levels in the PZFH contribute to the enhanced POD activity, which is further enhanced by accelerated surface electron transfer when exposure to alternated magnetic field. Accumulation of lipid peroxides is eventually accomplished through the conversion of ·OH radicals and singlet oxygen (1O2) produced through laser irradiation. When combined with the depletion of inhibition of glutathione and glutathione peroxidase 4, PZFH exhibits significantly enhanced ferroptosis in tumor-bearing mice, offering insights into nanomedicine for ferroptosis and holding great promise in clinical antitumor therapies.

Shaohui Lei; Zhuo Zou; Kangling Tian; Yan Zheng; Mei Ding; Guangxuan Hu
Chemical Communications, 2024 60 (59) - EI SCIE

摘要 : A W-doped Pt modified graphene oxide (Pt-W-GO) electrochemical microelectrode was developed to detect hydrogen peroxide (H2O2) in real time at a subcellular scale. Interestingly, results showed that the concentration of H2O2 in the nucleus of HeLa cells was 2.68 times and 0.51 times that in the extracellular membrane and cytoplasm, respectively.

Jianyu Yang; Ge Li; Shihong Chen; Xiaozhi Su; Dong Xu; Yueming Zhai
ACS Sensors, 2024 9 (4) - EI SCIE

摘要 : Urinary tract infections (UTIs), which can lead to pyelonephritis, urosepsis, and even death, are among the most prevalent infectious diseases worldwide, with a notable increase in treatment costs due to the emergence of drug-resistant pathogens. Current diagnostic strategies for UTIs, such as urine culture and flow cytometry, require time-consuming protocols and expensive equipment. We present here a machine learning-assisted colorimetric sensor array based on recognition of ligand-functionalized Fe single-atom nanozymes (SANs) for the identification of microorganisms at the order, genus, and species levels. Colorimetric sensor arrays are built from the SAN Fe1-NC functionalized with four types of recognition ligands, generating unique microbial identification fingerprints. By integrating the colorimetric sensor arrays with a trained computational classification model, the platform can identify more than 10 microorganisms in UTI urine samples within 1 h. Diagnostic accuracy of up to 97% was achieved in 60 UTI clinical samples, holding great potential for translation into clinical practice applications.

Rongfang Li; Zhiwei Jing; Guomin Yang; Ruo Yuan; Fang Xin Hu; Shihong Chen
Analytical chemistry (Washington), 2023 95 (49) - EI SCIE

摘要 : Owing to excellent catalytic activity, single-atom catalysts (SACs) have recently attracted considerable research interest in the electrochemiluminescence (ECL) field. However, the applications of SACs are mostly limited to conventional luminol ECL system. Hence, it is necessary to explore the application of SACs in more ECL systems. In this work, nickel single-atom catalysts (Ni SACs) were successfully applied in the graphitic carbon nitride (g-C3N4)–H2O2 ECL system to significantly enhance its cathodic emission. Notably, g-C3N4 acted not only as an ECL luminophore but also as a support to anchor Ni SACs. Ni SACs can significantly activate H2O2 to produce abundant OH• radicals for enhancing the cathodic ECL emission of g-C3N4. Ni SACs-anchored g-C3N4 (Ni SACs@g-C3N4) had a 10-fold enhanced ECL intensity as compared to g-C3N4. Finally, the Ni SACs@g-C3N4–H2O2 ECL system was developed to detect hepatitis B virus (HBV) DNA by incorporating an entropy-driven DNA walking machine-assisted CRISPR-Cas12a amplification strategy. The constructed biosensor exhibited excellent detection performance for HBV DNA with a limit of detection as low as 17 aM. This work puts forward a new idea for enhancing the cathodic ECL of g-C3N4–H2O2 and expands the application of SACs in the ECL system.

WANG Yechao; XIAO Yao; HU Fangxin; YANG Hongbin
Cailiao Daobao/Materials Review, 2023 37 (20) - EI

摘要 : With the increasing demand of low carbon emission reduction, the green hydrogen production technology has been paid great attention. Hydrogen production from water electrolysis using renewable energy is one of the lowest carbon emission method among many hydrogen producing technology. The water electrolysis process consists of hydrogen evolution reaction (HER) and water oxidation reaction (OER). OER undergoes a four electrons reaction, which presents a slow reaction kinetics and requires high overpotential as well as consumes high energy. At present, the lack of efficient and cheap OER catalyst has become the main bottleneck restricting the development of hydrogen production from electrolytic water. Compared with noble metal catalysts, stainless steel-based materials with high conductivity, low cost and excellent OER catalytic activity have attracted widespread attention. The investigations concerning further improve the electrochemical catalytic activity of stainless steel-based materials is the focus of current research. This paper reviews the research progress of stainless steel-based material towards OER, summarizes the strategies for improving the OER catalytic performance and finally prospects the development of stainless steel-based OER catalytic electrode. This paper will provide a very important reference for the investigation of water oxidation reaction of stainless steel based catalytic electrode.

Qiao Zhang; Hsin Jung Tsai; Fuhua Li; Zhiming Wei; Qinye He; Jie Ding
Angewandte Chemie (International ed. Internet), 2023 62 (44) - EI SCIE

摘要 : Single-atom catalysts exhibit superior CO2-to-CO catalytic activity, but poor kinetics of proton-coupled electron transfer (PCET) steps still limit the overall performance toward the industrial scale. Here, we constructed a Fe−P atom paired catalyst onto nitrogen doped graphitic layer (Fe1/PNG) to accelerate PCET step. Fe1/PNG delivers an industrial CO current of 1 A with FECO over 90 % at 2.5 V in a membrane-electrode assembly, overperforming the CO current of Fe1/NG by more than 300 %. We also decrypted the synergistic effects of the P atom in the Fe−P atom pair using operando techniques and density functional theory, revealing that the P atom provides additional adsorption sites for accelerating water dissociation, boosting the hydrogenation of CO2, and enhancing the activity of CO2 reduction. This atom-pair catalytic strategy can modulate multiple reactants and intermediates to break through the inherent limitations of single-atom catalysts.

Cun Wang; Fangxin Hu; Xia Feng; Xiaochuan Zou; Xin Zhao; Yanrong Ren
Food Chemistry, 2023 419 - EI SCIE

摘要 : In this work, a self-luminescent micron europium cluster coordination polymer (Eu-CCP) cathode electrochemiluminescence (ECL) emitter is first reported. The mass percentage of Eu in Eu-CCP is 50.1%, indicating that Eu-CCP has a high-nucleation luminescence center. In addition, our Eu-CCP possesses a stable and efficient ECL red emission performance, and the intensity is approximately 6.5-fold higher than that of the traditional tris(2, 2′-bipyridyl)ruthenium(II) dichloride. The enhancement of Eu-CCP luminescence in our system is due to the following reasons: (1) the mixed ligand and high nuclear europium luminescent center can cooperate to improve the quenching effect induced by water or hydroxyl groups; and (2) external coreaction accelerator and coreactant enhancement. We also investigate the application of Eu-CCP in ECL sensors by sensitive detection of tetracycline (TC). The low detection limit (73.5 fmol·L −1 ), high selectivity, good stability and satisfactory recoveries indicate that our ECL strategy can be used to detect TC accurately and sensitively.

Mengqi Tong; Ning Zhang; Zixuan Tan; Lili Chi; Kaiwen Zhang; Bo Chen
Microchemical journal (Print), 2023 190 - SCIE

摘要 : Improper treatment of highly active natural or edible water will cause environmental pollution, and hydrogen peroxide (H 2 O 2 ) is a common pollutant. Wide-range concentrations and short half-lift time of H 2 O 2 in different sample conditions make it a challenge for its accurate and fast detection. We present here the use of Bi 2 WO 6 nanocrystal with rich oxygen vacancy (Bi 2 WO 6 -V) to construct a photoelectrochemical (PEC) sensor for fast and wide-range qualification of H 2 O 2 . Under visible light irradiation, the H 2 O 2 detection limit of the Bi 2 WO 6 -V PEC sensor reaches 0.5 μM, which is 10 times that without light. The mechanism of PEC sensing performance toward H 2 O 2 was studied by UV–vis, Mott-Schottky characterization and PEC measurements, finding that the driving force of photogenerated electrons (−0.627 V) caused by energy level difference between Bi 2 WO 6 -V and the reduction of H 2 O 2 ensures that the visible light can be effectively absorbed to reduce H 2 O 2 to H 2 O. The calibration curve of H 2 O 2 obtained by the proposed PEC sensor regions from 1.5 μ M to 230 mM, with high response time and good selectivity. In addition, the sensor can detect H 2 O 2 in actual samples-milk and lake water, which has broad prospects in environmental monitoring.

Fang Xin Hu; Guangxuan Hu; Dong Ping Wang; Xinxuan Duan; Linrun Feng; Bo Chen
ACS Nano., 2023 17 (9) - EI SCIE

摘要 : Nitric oxide (NO) exhibits a crucial role in various versatile and distinct physiological functions. Hence, its real-time sensing is highly important. Herein, we developed an integrated nanoelectronic system comprising a cobalt single-atom nanozyme (Co-SAE) chip array sensor and an electronic signal processing module (INDCo-SAE) for both in vitro and in vivo multichannel qualifying of NO in normal and tumor-bearing mice. The high atomic utilization and catalytic activity of Co-SAE endowed an ultrawide linear range for NO varying from 36 to 4.1 × 105 nM with a low detection limit of 12 nM. Combining in situ attenuated total reflectance surface enhanced infrared spectroscopy (ATR-SEIRAS) measurements and density function calculation revealed the activating mechanism of Co-SAE toward NO. The NO adsorption on an active Co atom forms NO, followed by the reaction between NO and OH–, which could help design relevant nanozymes. Further, we investigated the NO-producing behaviors of various organs of both normal and tumor-bearing mice using the proposed device. We also evaluated the NO yield produced by the wounded mouse using the designed device and found it to be approximately 15 times that of the normal mouse. This study bridges the technical gap between a biosensor and an integrated system for molecular analysis in vitro and in vivo. The as-fabricated integrated wireless nanoelectronic system with multiple test channels significantly improved the detection efficiency, which can be widely used in designing other portable sensing devices with multiplexed analysis capability.

Yuhang Liu; Jie Ding; Fuhua Li; Xiaozhi Su; Qitao Zhang; Guangjian Guan
Advanced materials, 2023 35 (1) - EI SCIE

摘要 : Designing and synthesizing highly efficient and stable electrocatalysts for hydrogen evolution reaction (HER) is important for realizing the hydrogen economy. Tuning the electronic structure of the electrocatalysts is essential to achieve optimal HER activity, and interfacial engineering is an effective strategy to induce electron transfer in a heterostructure interface to optimize HER kinetics. In this study, ultrafine RhP2 /Rh nanoparticles are synthesized with a well-defined semiconductor-metal heterointerface embedded in N,P co-doped graphene (RhP2 /Rh@NPG) via a one-step pyrolysis. RhP2 /Rh@NPG exhibits outstanding HER performances under all pH conditions. Electrochemical characterization and first principles density functional theory calculations reveal that the RhP2 /Rh heterointerface induces electron transfer from metallic Rh to semiconductive RhP2 , which increases the electron density on the Rh atoms in RhP2 and weakens the hydrogen adsorption on RhP2 , thereby accelerating the HER kinetics. Moreover, the interfacial electron transfer activates the dual-site synergistic effect of Rh and P of RhP2 in neutral and alkaline environments, thereby promoting reorganization of interfacial water molecules for faster HER kinetics.